The effects of aqueous cinnamon bark extract and cinnamaldehyde on neurons of substantia nigra and behavioral impairment in a mouse model of Parkinson’s disease

Authors

Abstract:

Background and Objective: Parkinson's disease (PD) is characterized by a progressive loss of dopaminergic neurons in substantia nigra. In recent years, there have been interests in the role of the free radical damage in PD. Cinnamon and its derivative, cinnamaldehyde acts as powerful antioxidant and anti-inflammatory agents. This research focused on the effects of cinnamon extract and cinnamaldehyde on neurons of SNc of a mouse model of Parkinson’s disease. Materials and Methods: 45 adult male mice with an average weight of 25-35 g were divided into 9 groups of 5 each: group 1: control PBS, group 2: control serum, group 3: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), group 4: MPTP + low dose of cinnamon extract pretreatment (20 mg/kg), group 5: MPTP+ high dose of cinnamon extract pretreatment (40 mg/kg), group 6: MPTP + low dose of cinnamon extract treatment (20 mg/kg), group7: MPTP + high dose of cinnamon extract treatment (40 mg/kg), group 8: MPTP + cinnamaldehyde pretreatment (30 mg/kg), group 9: MPTP+ cinnamaldehyde treatment (30 mg/kg). Rotarod test was used to assess motor and balance of the mice. After behavioral studies, all mice were anesthetized and perfused transcardially with 0.1 M PBS (PH=7.4) followed by 4% buffered paraformaldehyde fixative. The brain of the mice were removed and fixed in the paraformaldehyde and stained for Nissl and the number of Nissl-stained neurons were counted. Data was analyzed using SPSS software by one way ANOVA. Results: Aqueous cinnamon extract and cinnamaldehyde improved rotarod performance of MPTP-lesioned mice and prevented loss of Nissl-stained neurons of SNc of the midbrain. Conclusion: These findings suggest that cinnamaldehye as a natural antioxidant may protect  neurons of SNc neurons against Parkinson’s disease.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

the effects of aqueous cinnamon bark extract and cinnamaldehyde on neurons of substantia nigra and behavioral impairment in a mouse model of parkinson’s disease

background and objective: parkinson's disease (pd) is characterized by a progressive loss of dopaminergic neurons in substantia nigra. in recent years, there have been interests in the role of the free radical damage in pd. cinnamon and its derivative, cinnamaldehyde acts as powerful antioxidant and anti-inflammatory agents. this research focused on the effects of cinnamon extract and cinn...

full text

on translation of politeness strategies in dialogues involving female characters in translations and retranslations of novels translated before and after the islamic revolution of iran and their effects on the image of women: a polysystem theory approach

abstract reception environment has considerable effects on accepting a translation. as the expectations of a target culture and its values and needs change throughout history, its criteria for accepting a translation or rejecting it will change accordingly (gentzler, 2001). the expectations of iran, as the reception environment in the present study, have changed after the islamic revolution. i...

the effect of aqueous extract of garlic on formalin-induced pain in male rats

چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...

15 صفحه اول

the effects of planning on accuracy and complexity of iranian efl students’ written narrative task performance

this study compared the different effects of form-focused guided planning vs. meaning-focused guided planning on iranian pre-intermediate students’ task performance. the study lasted for three weeks and concentrated on eight english structures. forty five pre-intermediate iranian students were randomly assigned to three groups of guided planning focus-on-form group (gpfg), guided planning focus...

15 صفحه اول

the effects of time planning and task complexity on accuracy of narrative task performance

هدف اصلی این تحقیق بررسی تاثیر برنامه ریزی زمانی، هم چنین افزایش میزان پیچیدگی تکالیف در نظر گرفته شده بصورت همزمان، بر دقت و صحت و پیچیدگی عملکرد نوشتاری زبان آموزان می باشد. بدین منظور، 50 نفر از دانش آموزان دختر در رده ی سنی 16 الی 18 سال به عنوان شرکت کنندگان در این زمینه ی تحقیق در نظر گرفته شدند و به دو گروه آزمایشی و کنترل بصورت اتفاقی تقسیم شدند. اعضای گروه آزمایشی هر دو تکلیف ساده و پی...

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 5  issue 1

pages  27- 32

publication date 2017-03-01

By following a journal you will be notified via email when a new issue of this journal is published.

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023